Invasive Burmese pythons are taking over the Florida Everglades and devouring everything in sight. The only way to stop them is to call in the nation’s best swampers: King of the Swamp Troy Landry, his son Chase, legendary gator hunter Bruce Mitchell, and big fish wrangler Zak Bagby. Together with professional snake hunter Bill Booth, the men dive into the underbelly of the Everglades to capture and remove the sinister beasts.

One week into the hunt for invasive Burmese pythons, the swampers venture into the foreboding Everglades Triangle. Bruce, Zak and Bill hunt near a mysterious abandoned rocket silo, while Troy and Chase scour a cattle ranch for one of the world’s deadliest snakes: the African Rock Python.

In the third week of fighting monster serpents, hunters face a terrifying reality: the invasion is bigger than they anticipated. With their backs against the wall, Troy, Chase and Bill call upon trackers and thermal drones to get a leg up on the snakes. Meanwhile, Bruce and Zak breakdown in the middle of a swamp that’s rumored to be home to the largest serpent in the world–the green anaconda.

As the hunters face their final week in the Everglades, Troy and Chase protect a remote community from an aggressive gang of alligators. Then, the swampers join forces to track down a deadly hybrid python. Will they be able to stop the rise of the super snakes’

The Cajun Navy is back to fight the war against pythons invading the Everglades. King of the Swamp Troy Landry, along with his son Chase and snake expert Bill Booth, track serpents into a breeding ground known as Deer Haven. Meanwhile, veteran swamper Bruce Mitchell and invasive species hunter, Zak Catchem, take on the legendary Skunk Ape Alley, an area known for strange encounters and massive pythons.

As the hunting season heats up, Troy, Chase and Bill dive into deep water to catch pythons, but might be in over their heads. Meanwhile, Bruce and Zak fear they've bitten off more than they can chew when they venture into Viper Jungle, an area filled with venomous rattlesnakes and moccasins.

The hunters venture into the Everglades Triangle, an area known for mysterious disappearances and swarms of snakes; Troy, Chase and Bill use a drone to search the swamp from the air, while Bruce and Zak track snakes with a handheld thermal device.

When Troy, Chase and Bill mount an airboat to hunt an area pythons are raiding alligator nests, an unfortunate mishap could leave them stranded overnight. Meanwhile, Bruce and Zak's journey into an abandoned ghost town with a haunted past, leads them to an unexpected opportunity.

Troy, Chase, and Bill gamble on a long journey into the center of the Everglades, following the migration of giant pythons to the furthest depths of the wetlands. Meanwhile, Bruce and Zak head deep into outlaw country, looking for snakes hiding on a deserted bootlegging trail...but what they uncover is far more shocking than they expected.

A friendly wager on which team can catch the most snakes and the biggest python; Troy, Bill and Chase return to a honey hole from last season, while Zak and Bruce place their bets on an abandoned Cold War bomb shelter.

As a heat wave grips the Everglades, Bruce and Zak call in canine reinforcements to sniff out serpents hiding from the rising temperature. Meanwhile, Troy, Chase, and Bill hunt the remote jungles of snake island. But when a differing opinion on strategy divides them, Troy soon finds himself alone in the middle of nowhere.

All five hunters converge on the northern edge of the Everglades to stop the invasion of serpents into a critical bird sanctuary.

'King of the Swamp' Troy Landry teachers long time alligator hunting partner Pickle Wheat the ins and outs of Python hunting, but sometimes even the most experienced hunter's walk away with scars. Meanwhile, veteran snake hunter Bill Booth and Florida hunter Tes Lee must learn to work as a team if they hope to put a dent in the growing Python population. Zak and newcomer Aaron hunt Pythons in an ancient canal system and almost get in over their heads. Dusty Crum finds the fight for the Everglades knocking at his front door.

Pickle must face her fear of big cats as she continues to impress Troy with her natural snake hunting talent. Bill and Tes's hunt stumble on a rumored government testing facility and find all they can handle. Dusty recruits a new hunting partner with a snake phobia while Zak and Aaron battle pythons and the supernatural.

Troy and Pickle hunt a giant python known as the Night Serpent. Tess convinces Bill to try out new hunting grounds, but Bill is not sure it's a good idea. Zak and Aaron explore a notorious corner of the Everglades, and Dusty Crum has an idea to lighten his load.

Troy and Pickle witness how far the pythons have spread; Zak and Aaron take on a new type of beast; Bill and Tess tackle some uninvited guests; Dusty does what he can to prevent an early end to his python season.

Troy and Pickle face a familiar foe while Bill and Tes defend a friend's camp from a slithering invasion; Zak and Aaron's hunt leaves a bad taste in their mouths, and Dusty Crum has a plan to work smarter not harder.

Troy Landry and Pickle Wheat get a tip about a place called the snake pit from a local; Bill and Tes investigate a rock quarry full of pythons; Dusty has a close call with the supernatural, while Zak and Aaron fight to protect the local children.

The battle for the Everglades becomes personal for Troy and Pickle; Bill and Tes venture further north than ever before; Zak and Aaron visit Zak's childhood stomping grounds; Dusty heads to one of his favorite honey holes.

Hunter Bruce Mitchell joins the fight with Zak and Aaron; Troy, Pickle, Bill and Tes team up to help a rancher with a serious problem; Dusty devises a way to light up the night.

Troy and Pickle battle a hyper aggressive breed of python. Bill and Tes try to stay one step ahead of the Army Corp of Engineers. Dusty works on a plan to get the snakes to come to him, while Zak and Bruce face off against two foes.

Troy Landry and Pickle Wheat mix it up with some locals; Tes puts her skills to the test hunting without her partner, Bill; Zak and Bruce return to Viper Alley; Dusty hunts for a legend.

Troy and Pickle track a high-tech snake; Bill and Tes search for a new hot spot; Dusty discovers one of his favourite honey holes has changed forever; Zak and Bruce chase the snakes below ground and get a surprise.

Troy and Pickle help a friend look for his lost dog; Bill and Tes search for pythons in a spot ravaged by wildfires; Zak and Bruce investigate an abandoned boatyard; Dusty hunts in an area with a dark past.

Bill and Tes battle the Everglades heat; Troy and Pickle search for a python paradise; a special day for Dusty goes awry; Zak and Bruce try their luck in the Dead Zone.

Troy and Pickle help rid a citrus grove of pythons; Bill is forced to hunt solo for the day; Bruce and Zak mount an airboat to a new honey hole; Dusty responds to a friend's call for help.

The clock is ticking with only days remaining in python season; Pickle seeks validation from Troy on her tracking skills; Bruce must hunt alone in Zak's absence; Dusty heads to an isolated portion of the Everglades.

On the last day of the season, the hunters gather to target breeding females; Bill and Tes investigate a secluded stretch of islands; Dusty hopes to go out with a bang, while Zak and Bruce follow an ancient native trail.

Hunters return to the Everglades to find the enemy transformed. Giant female pythons have learned to hide from their pursuers, allowing them to breed faster than ever. Now the swampers must dive deep into their secret lairs and remove the beasts before the glades are lost forever.

Troy and Tes race a mounting storm. Zak and Bruce battle an invasion of deer-eating beasts. Ashley and Kaylyn search for a legendary monster. Dusty hatches a daring plan to strike it rich.

Ashley and Kaylyn charge onto Bear Ridge; Zak and Bruce answer an urgent call for help; Troy and Tes go into battle to defend a bird sanctuary; Dusty puts on his inventor hat to save the Glades.

Troy and Tes chase a legendary monster; Dusty changes plans on the fly to save a friend; Zack and Bruce bet big on logging country; Ashley and Kaylyn break into a jungle in search of a python honey hole.

As the Everglades suffer a sudden dry spell, Troy and Tes gamble on a voyage to the glades' tree islands. Ashley and Kaylyn hunt along a river full of gators. Zak and Bruce sweat it out on a kayak mission down the canals.

Troy and Tes search for a beast terrorizing a local camp. Ashley and Kaylyn hunt in the wake of Hurricane Ian's destruction. Zak and Bruce return to Monster Highway. Dusty launches a new business venture.

Ashley and Kaylyn enlist the help of a blind hunting dog. Dusty bets his fortunes on Python Palace. Troy and Tes investigate rumors of an old camp infested with pythons. Hunting solo, Zak struggles to penetrate a cypress forest.

Troy and Tes hunt in the wake of a prescribed burn. Zak and Bruce try to break a cold streak on Bruce's last day in the Everglades. Dusty confronts an enemy invader. Ashley and Kaylyn hit an unexpected dead end.

Zak and Aaron combat an invasion in Zak's neighborhood. Tes works alone in the depths of buggy country. Ashley and Kaylyn hunt near a camp with a haunting past. Dusty chases an old nemesis.

Troy and Tes hunt for a horse-killing gator. Zak and Aaron gamble on the Dead Sea. Ashley and Kaylyn explore a distant honey hole. Dusty launches a new scheme.

Troy and Tes gamble on new hunting grounds; Ashley and Kaylyn follow an old surveyor's trail; Zak and Aaron place their bets on Bad Luck Prairie; Dusty resurrects an old boat to reach distant honey holes.

Zak and Aaron make a bet with Ashley and Kaylyn to reignite their seasons. Troy and Tes voyage to the cypress strand in the middle of the Glades. Dusty puts his swamp bartering skills to the ultimate test.

Troy and Tes venture into gator territory. Zak and Aaron chase a hog-eating monster. Ashley and Kaylyn hunt the edges of a wildfire. Dusty launches a new business venture.

As a heatwave scorches the Everglades, Troy and Tes intercept pythons charging toward the rivers. Zak and Aaron venture far west to a remote canal. Ashley and Kaylyn gamble on an all-night hunt. Dusty scavenges for his next meal.

Troy and Tes discover a new hot spot. Zak and Aaron encounter unexpected company. Ashley and Kaylyn hunt the notorious Camel Hump. Dusty trains the next generation of hunting dog.

In the final hours of python season, hunters launch a full assault to win the battle against the vicious invaders. With the clock ticking to save the Everglades, teams race back to old honey holes to track down the most elusive beasts, while Dusty bids farewell to his longtime partner.

Zak and Aaron team up with a gladesman promising to bring them to a python jackpot and Troy gets his old partner Pickle back into fighting shape; and Bruce and Kaylyn return to a monster's den.

Troy and Pickle call in a chopper to reach a remote hunting spot deep in the Everglades and Zak and Aaron attempt a bold new strategy using fish chum to attract snakes.

The teams unite to storm a hostile site that's rumored to be swarming with pythons.

Troy and Pickle struggle to take command of a friend's hunting dog and Zak and Aaron deploy kayaks deep into an untested area.

As the excessive heat begins to wear on the hunters, the King of the Swamp launches a contest to catch the biggest python.

Pickle learns to drive an airboat on the fly and Zak and Aaron go after two invasive species at once.

The hunters push past the point of exhaustion in the final stretch of python season, tempting fate in panther country, gambling on isolated hotspots and searching into the dead of night.

The hunters go to Lake Elizabeth Wetlands and battle with pythons, pushing their limits.